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Effect of Testosterone on Response to Sildenafil in Men With Erectile Dysfunction FREE

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The full report is titled “Effect of Testosterone Replacement on Response to Sildenafil Citrate in Men With Erectile Dysfunction. A Parallel, Randomized Trial.” It is in the 20 November 2012 issue of Annals of Internal Medicine (volume 157, pages 681-691). The authors are M. Spitzer, S. Basaria, T.G. Travison, M.N. Davda, A. Paley, B. Cohen, N.A. Mazer, P.E. Knapp, S. Hanka, K.M. Lakshman, J. Ulloor, A. Zhang, K. Orwoll, R. Eder, L. Collins, N. Mohammed, R.C. Rosen, L. DeRogatis, and S. Bhasin.

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Ann Intern Med. 2012;157(10):I-18. doi:10.7326/0003-4819-157-10-201211200-00001
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What is the problem and what is known about it so far?

Sildenafil does not restore erectile function in all men who have erectile dysfunction (ED). For this reason, some doctors prescribe sildenafil plus testosterone to men with ED who have low testosterone levels in their blood.

Why did the researchers do this particular study?

There is little evidence about the effectiveness of using sildenafil plus testosterone to treat ED.

Who was studied?

Men aged 40 to 70 years who had ED and low testosterone levels.

How was the study done?

Researchers divided the men into 2 groups, started all participants on low-dose sildenafil, and increased the dose until erections were satisfactory or participants reached the maximum dose. Men in both groups continued the sildenafil and started applying gel onto their skin each day. In 1 group, the gel contained testosterone; in the other, the gel was a placebo.

What did the researchers find?

When the study started, men in the 2 groups had similar levels of ED and showed similar improvement on sildenafil alone; however, there were only small additional changes after the men started using the gels.

What were the limitations of the study?

This study did not examine whether testosterone can improve erectile function without sildenafil.

What are the implications of the study?

Physicians can prescribe sildenafil alone to treat ED in men who have low testosterone levels.





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