The articles in the supplement provide important opportunities for the future. Success depends on multiplicity of factors, including policies, reimbursement models, health care delivery models, systems, education, and financing. Critical to all of them is the role of the individual physician who is fully committed to the effort and is adaptable in a changing world in which bundles, protocols, team care, electronic data collection, and evidence-based treatment paradigms are undertaken. Historically, when physicians have not responded to the key elements of health care, such as access, cost, and quality, others have imposed solutions on them. Quality of care remains the arena in which physician leadership can still provide direction, innovation, and enhanced satisfaction for patients and caregivers.