After the onset of menopause, women may experience an increase in cardiovascular disease (CVD), such as coronary artery disease leading to heart attacks, in addition to hot flashes and other uncomfortable changes. Menopausal hormone therapy (MHT), sometimes called hormone replacement therapy, has been used to help alleviate symptoms of menopause, such as hot flashes. This therapy might also reduce a woman's risk for CVD, although a large clinical trial of this treatment in predominantly older menopausal women did not find such a benefit. It has been observed that women who were receiving MHT closer to the onset of menopause may have a lower rate of CVD. However, this information does not come from a clinical trial, which could more definitively establish whether such a benefit exists.