We share COMPare's overarching goals to ensure the validity and reporting quality of biomedical studies, but we differ on how best to achieve those aims. We routinely ask authors of clinical trials to submit their protocols with their manuscripts, and we examine trial registries for the initial and final information entered about trials. We review both items because registries include only extracted information, do not routinely monitor whether the data in the registry match the protocol, and may not be updated when the protocol changes. We therefore rely primarily on the protocol for details about prespecified primary and secondary outcomes, study interventions and procedures, and statistical analysis. To be consistent with CONSORT recommendations, we ask authors to describe, either in the manuscript or in an appendix, any major differences between the trial registry and protocol, including changes to trial end points or procedures.