The 2009 U.S. Preventive Services Task Force (USPSTF) recommendations on breast cancer screening ignited a firestorm (1). Seven years later, the draft updated recommendations, which were available for public comment from 20 April to 18 May 2015, rekindled the fire (2). Sparks included full-page advertisements, likely costing up to a half-million dollars and appearing in such venues as The New York Times, USA Today, and The Washington Post, that asked, "Which of our mothers, wives, daughters, and sisters would it be OK to lose?" The named sponsors of the ad—Bright Pink, the Black Women's Health Imperative, the National Medical Association, the National Hispanic Medical Association, Men Against Breast Cancer, and the Prevent Cancer Foundation—urged readers to sign a petition to "stop the guidelines" (bit.ly/StopTheGuidelines). Flames, fueled by controversy about the grade C screening recommendation for women aged 40 to 49 years, spread to the halls of Congress.