Colorectal cancer is cancer of the colon (large intestine) or rectum. Screening decreases deaths due to colorectal cancer by detecting precancerous abnormalities (polyps) and removing them before they become cancerous and by detecting cancer in an early stage when it can still be cured with surgery. Chemoprevention is another strategy to prevent colorectal cancer. Chemoprevention means taking a drug to reduce the risk for a disease. Studies suggest that taking high doses of daily aspirin or a nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, may reduce a person’s risk for polyps and colorectal cancer. However, theses drugs have side effects. Whether people should routinely take aspirin or NSAIDs to reduce their risk for colorectal cancer depends on whether the benefits of colorectal cancer reduction outweigh the risks for side effects.