104 patients got placebo, and 108 got fluconazole. Proven fungal infections occurred in 45 of 104 patients on placebo and in only 10 of 108 patients on fluconazole. Fluconazole prevented both mild fungal infections (like infections of the skin) and serious fungal infection (like infections in the blood). However, patients on fluconazole were as likely to die during the study as were patients who got placebo. Fungal infection was less likely to be the cause of death for patients on fluconazole. Fluconazole did not seem to cause any liver damage in the patients who got it. However, patients who got fluconazole were more likely than patients who got placebo to suffer from such side effects as headaches, shakes, and even seizures. The researchers found that these side effects developed because the patients on fluconazole developed high levels of another medication, cyclosporine, which many liver transplant patients get. Fluconazole seems to change the way people handle cyclosporine so that lower doses are necessary to get the same blood levels of cyclosporine.