Colon cancer is cancer of the large intestine. If colon cancer is found in its early stages, it can often be successfully treated with surgery. If colon cancer has spread outside of the colon to the lymph nodes (node-positive colon cancer), the addition of chemotherapy that includes the drug 5-fluorouracil (5-FU) helps patients survive longer. However, such treatment is less common in patients 65 years of age and older than it is among younger patients. Some think that doctors are reluctant to advise older patients to have chemotherapy because studies of 5-FU therapy have included few older patients. It is not known whether older patients do as well after 5-FU therapy as younger patients.