Histoplasmosis is a serious fungal infection that occurs in as many as 5% to 20% of people with HIV infection. The standard initial treatment for severe histoplasmosis is a drug called amphotericin B. Amphotericin B is usually given daily, through a vein, for a few weeks. Later, a different antifungal drug that can be taken by mouth is given for several months. Many side effects, such as fever, chills, nausea, and problems with kidney function, can occur with standard preparations of amphotericin B. New preparations of amphotericin B that do not have as many side effects are needed.