Polymyalgia rheumatica is a condition characterized by pain and stiffness in the muscles around the shoulders and hips. The cause is unknown. Polymyalgia rheumatica most often occurs in women older than 50 years of age. In addition to muscle pain, some patients with polymyalgia rheumatica have a sense of feeling unwell (malaise), fatigue, fever, night sweats, or weight loss. Doctors usually treat polymyalgia rheumatica with oral corticosteroids (prednisone). Prednisone relieves symptoms, but patients often need to take it for a long time, and long-term use may cause side effects, such as bone loss. Thus, doctors and patients would like to find a way to treat polymyalgia rheumatica that decreases the need for long-term prednisone therapy.