People commonly use nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain. Examples of older NSAIDs include aspirin, ibuprofen (Advil or Motrin), and naproxen (Aleve). Although these older NSAIDs are fairly safe, they can irritate the lining of the stomach and can cause ulcers and bleeding. Cyclooxygenase-2 (COX-2) inhibitors are a new type of selective NSAIDs. Examples of COX-2 inhibitors are celecoxib (Celebrex), rofecoxib (Vioxx), and valdecoxib (Bextra). They inhibitors do not injure the stomach lining as much as older NSAIDs do and cause fewer stomach problems and ulcers. However, they also cost more and require a doctor's prescription. Also, some COX-2 inhibitors increase the risk for heart disease. For example, rofecoxib was withdrawn from the market in September 2004 because a large trial found that it increased the risk for heart attacks and strokes. We do not know whether other COX-2 inhibitors have similar or different risks.