People commonly use nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain. Examples of NSAIDs include aspirin, etodolac (Lodine), ibuprofen (Advil or Motrin), and naproxen (Aleve). NSAIDs can irritate the lining of the stomach and cause ulcers and bleeding. Drugs called cyclooxygenase-2 (COX-2) inhibitors are a particular “selective” type of NSAID that may not injure the stomach lining as much as other NSAIDs. Examples of COX-2 inhibitors are celecoxib (Celebrex), meloxicam (Mobicox), rofecoxib (Vioxx), and valdecoxib (Bextra). Some COX-2 inhibitors may increase the risk for heart disease. For example, rofecoxib was withdrawn from the market in September 2004 because a large trial found that it increased the risk for heart attacks and strokes. We do not know whether other COX-2 inhibitors and nonselective NSAIDs have similar or different risks.