Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Many people take ibuprofen or other NSAIDs for headache, musculoskeletal problem, and other types of pain. Platelets are the blood cells that help the blood to clot. Ibuprofen and other NSAIDs may affect the way platelets work and could interfere with normal blood clotting. Blood clotting is very important during surgery, so many doctors advise patients to stop taking ibuprofen and other NSAIDs at least 1 week before surgery. However, the effect of NSAIDs on platelets is temporary. No studies directly support the recommendation to stop the drugs 7 days before surgery.