Summaries for Patients |

Tiotropium and the Treatment of Chronic Obstructive Lung Disease FREE

[+] Article, Author, and Disclosure Information

The summary below is from the full report titled “Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease with Tiotropium, a Once-Daily Inhaled Anticholinergic Bronchodilator. A Randomized Trial.” It is in the 6 September 2005 issue of Annals of Internal Medicine (volume 143, pages 317-326). The authors are D.E. Niewoehner, K. Rice, C. Cote, D. Paulson, J.A.D. Cooper Jr., L. Korducki, C. Cassino, and S. Kesten.

Ann Intern Med. 2005;143(5):I-20. doi:10.7326/0003-4819-143-5-200509060-00002
Text Size: A A A

What is the problem and what is known about it so far?

Chronic obstructive pulmonary disease (COPD) is a cigarette-associated abnormality of the lungs that is characterized by destruction of lung tissue and inflammation of the bronchial tubes. People with COPD usually notice chronic shortness of breath, cough, and wheezing (caused by spasm of the bronchial tubes). They may also experience abrupt worsening of their symptoms. These episodes are called exacerbations. Tiotropium is a new drug that relaxes bronchial spasm and seems to be effective in easing the chronic symptoms of COPD. Whether tiotropium is effective for preventing COPD exacerbations is less clear.

Why did the researchers do this particular study?

To see whether tiotropium could prevent exacerbations and decrease hospitalizations for COPD exacerbations.

Who was studied?

1829 patients older than 40 years of age who had moderate to severe COPD and were being cared for at Veterans Affairs Medical Centers.

How was the study done?

Researchers randomly assigned patients to receive either tiotropium or placebo (a look-alike but fake medication with no active ingredients). They collected information on symptoms and hospitalizations for COPD every month for 6 months. They then compared the number of exacerbations and hospitalizations in the 2 groups.

What did the researchers find?

Fewer patients receiving tiotropium had exacerbations than those receiving placebo. Tiotropium also reduced the number of hospitalizations for COPD exacerbations.

What are the limitations of the study?

Almost all patients were men, so the findings might not apply equally to women. The researchers compared the groups for only 6 months, and findings might differ over longer periods of time. Also, the researchers compared tiotropium with placebo, not with other drugs that are commonly used for treating COPD.

What are the implications of the study?

Tiotropium seems to be effective in reducing exacerbations and hospitalizations in patients with COPD. It is not necessarily more effective than other drugs commonly used to treat COPD.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.