Many people get Chagas disease as children. There are 3 stages of Chagas disease: acute, indeterminate, and chronic. The acute stage is early infection. Fever, fatigue, rash, and enlarged liver, spleen, and lymph nodes can occur in this stage, but these symptoms usually are not severe and often resolve even without treatment. After the acute stage, the indeterminate stage can last many years with the person still having the infection in their blood but no symptoms. Chronic disease occurs in up to one third of people with Chagas disease. In this stage, symptoms of heart or gastrointestinal tract problems develop 10 years or more after the initial infection. Treatment involves drugs, such as benznidazole, that kill the parasite. Treatment is effective during acute-stage Chagas disease, but its effectiveness during nonacute disease (indeterminate and chronic stages) is uncertain.