Polymyalgia rheumatica (PMR) is a disease in which inflammation occurs throughout the body. Symptoms include weight loss; fever; muscle pain; aching of the neck, shoulder, and hip; and morning stiffness. The cause of PMR is unknown. It occurs most often in persons older than 50 years of age and increasingly often with advancing age. Polymyalgia rheumatica responds well to treatment with steroids, such as prednisone. However, patients usually need to stay on steroids for 1 to 2 years, and symptoms sometimes return (relapse) when steroid treatment is stopped. Patients can develop side effects from steroids, so we need better ways to treat PMR to decrease relapse and the amount of steroids needed to treat the disease. Infliximab is a drug that interacts with the immune system. A report suggested that infliximab decreased the amount of steroids needed in 4 patients with PMR who developed side effects from steroid treatment.