0
Summaries for Patients |

What Aspirin Dose Is Safest and Most Effective for Preventing Heart Disease? FREE

[+] Article and Author Information

The summary below is from the full report titled “Aspirin to Prevent Cardiovascular Disease: The Association of Aspirin Dose and Clopidogrel With Thrombosis and Bleeding.” It is in the 17 March 2009 issue of Annals of Internal Medicine (volume 150, pages 379-386). The authors are S.R. Steinhubl, D.L. Bhatt, D.M. Brennan, G. Montalescot, G.J. Hankey, J.W. Eikelboom, P.B. Berger, and E.J. Topol, on behalf of the CHARISMA Investigators.


Ann Intern Med. 2009;150(6):I-22. doi:10.7326/0003-4819-150-6-200903170-00001
Text Size: A A A

What is the problem and what is known about it so far?

Aspirin and clopidogrel (Plavix) are drugs that block the ability of platelets to stick together and form clots. Because the drugs prevent clotting, they may also cause bleeding. Doctors often prescribe daily aspirin to prevent future blood clots in people who have had or are at high risk for heart attacks and strokes. In these groups, the benefits of preventing clots outweigh the risk for bleeding. However, different doses of aspirin may have different benefits and risks. For example, lower aspirin doses may cause less bleeding but may be less effective at preventing clots. Also, higher aspirin doses may be more effective at preventing clots but may cause more bleeding.

Why did the researchers do this particular study?

To see which dose of aspirin seems to be safest and most effective.

Who was studied?

Almost 15 600 people at risk for heart attack and stroke who were taking aspirin. All had been participants in a study of whether clopidogrel and aspirin prevented more heart attacks and strokes than aspirin alone.

How was the study done?

The researchers grouped together participants who were taking lower and higher aspirin doses. They then followed them over time and compared the number of people in each group who died or had heart attacks, strokes, or bleeding events.

What did the researchers find?

Outcomes did not obviously differ between people who took lower and higher aspirin doses. However, people who took higher aspirin doses together with clopidogrel may have been slightly more likely to die or have a heart attack, stroke, or bleeding event.

What were the limitations of the study?

The findings are not definitive because participants were not assigned at random to receive higher and lower aspirin doses.

What are the implications of the study?

Higher daily aspirin doses are not clearly better than lower doses. Higher doses may cause more harm, especially for people taking clopidogrel. Lower doses may be equally effective and safer.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Aspirin resistance in adult patients after Fontan surgery. Int J Cardiol Published online Nov 27, 2014.;
Clinical and Epidemiological Characteristics of Kawasaki Disease. Jundishapur J Microbiol 2014;7(8):e11014.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)