Should specific subgroups of women aged 40 to 49 years receive screening mammography—if so, at what interval? Notably, the updated USPSTF recommendations do not provide specific recommendations for women at high risk for breast cancer because sufficient evidence does not exist to make such recommendations. Screening recommendations for women aged 40 to 49 years with a first-degree relative with breast cancer could be made on the grounds that risk for disease in these women is similar to that of women aged 50 to 59 years (14). Four of the 6 models show no additional deaths were averted by annual versus biennial screening of women aged 40 to 49 years (8). Randomized, controlled trials that screened women aged 40 to 49 years annually compared with biennially have similar summary breast cancer mortality reductions of 11% (95% CI, −26% to 1%) and 17% (CI, −33% to 3%), respectively (7). Thus, if women aged 40 to 49 years choose to have screening mammography, they can schedule screening biennially, which will limit false-positive results and additional imaging (7–8).