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Hypomagnesemia Induced by Several Proton-Pump Inhibitors

Maarten A.C. Broeren, PhD; Engelien A.M. Geerdink, MD; Huib L. Vader, PhD; and A. Warmold L. van den Wall Bake, MD, PhD
[+] Article, Author, and Disclosure Information

From Máxima Medical Centre, 5500 MB Veldhoven, The Netherlands.

Potential Conflicts of Interest: None disclosed.

Ann Intern Med. 2009;151(10):755-756. doi:10.7326/0003-4819-151-10-200911170-00016
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Profiles of serum magnesium, serum calcium, serum potassium, and urinary magnesium excretion during treatment with various proton-pump inhibitors and ranitidine.

The normal ranges for the serum variables are indicated by the shading; the time of treatment of the various drugs is indicated at the top.

* Corrected calcium concentration: [Ca] = [Ca]measured − 0.013 * [Albumin] + 0.56.

Grahic Jump Location




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Hypomagnesemia by PPI's
Posted on November 28, 2009
Sourabh Aggarwal
University College of Medical Sciences
Conflict of Interest: None Declared

It is quite an interesting finding reported by the authors and I applaud them for the same. It is a matter of serious concern considering that Proton pump Inhibitors are being increasingly prescribed by practitioners all over the world, even for non specific epigastric pain and for placebo effect in some cases. Considering the wide use of PPIs and seriousness of the symptoms caused by hypomagnesemia, the clinicians should develop high index of suspicion in cases with similar presentation. Though it is quite preliminary to generalize the hypomagnesemia side effect to other PPIs, developing high index of suspicion can help report similar findings especially considering the fact that magnesium measurements are being rarely done in the routine clinics. It will greatly enhance our understanding of the risk profile of the PPIs.

Conflict of Interest:

None declared

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