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To Screen or Not to Screen Women in Their 40s for Breast Cancer: Is Personalized Risk-Based Screening the Answer?

Jeanne S. Mandelblatt, MD, MPH; Natasha Stout, PhD; and Amy Trentham-Dietz, PhD
[+] Article, Author, and Disclosure Information

From Lombardi Comprehensive Cancer Center, Washington, DC 20057; Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215; and University of Wisconsin Carbone Cancer Center, Madison, WI 53792.

Grant Support: By grants U01 CA00905, UO1CA088283, U01CA152958, KO5CA096940 (Dr. Mandelblatt), R01 CA067264 (Dr. Trentham-Dietz), U01CA086076-10S1, and RC2 CA148577 from the National Institutes of Health and grant 118223-MRSG-10-002-01-CPHPS from the American Cancer Society (Dr. Stout).

Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1100.

Requests for Single Reprints: Jeanne S. Mandelblatt, MD, MPH, Lombardi Comprehensive Cancer Center, 3300 Whitehaven Street Northwest, Suite 4100, Washington, DC 20057; e-mail, mandelbj@georgetown.edu.

Current Author Addresses: Dr. Mandelblatt: Lombardi Comprehensive Cancer Center, 3300 Whitehaven Street Northwest, Suite 4100, Washington, DC 20057.

Dr. Stout: Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215.

Dr. Trentham-Dietz: University of Wisconsin Carbone Cancer Center, 610 Walnut Street, WARF Building, Room 307, Madison, WI 53726.

Ann Intern Med. 2011;155(1):58-60. doi:10.7326/0003-4819-155-1-201107050-00008
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In this issue, Schousboe and colleagues report on a cost-effectiveness model to estimate the outcomes of mammography screening in a hypothetical cohort of U.S. women with varying risk for breast cancer. The editorialists discuss the innovations in Schousboe and colleagues' approach and the obstacles that remain to using such factors as breast density to refine current screening guidelines.


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