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Editorials |

Who Should Have Genetic Testing for the Lynch Syndrome?

Randall W. Burt, MD
[+] Article, Author, and Disclosure Information

From University of Utah and Huntsman Cancer Institute, Salt Lake City, UT 84112.

Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1308.

Requests for Single Reprints: Randall W. Burt, MD, Division of Gastroenterology, Department of Internal Medicine, University of Utah School of Medicine, Huntsman Cancer Institute at the University of Utah, 2000 Circle of Hope, Room 5164, Salt Lake City, UT 84112; e-mail, randall.burt@hci.utah.edu.

Ann Intern Med. 2011;155(2):127-128. doi:10.7326/0003-4819-155-2-201107190-00009
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Determining who should have genetic testing for the Lynch syndrome remains problematic. In this issue, Ladabaum and colleagues' cost-effectiveness analysis concluded that the preferred approach was tumor immunohistochemistry for all persons with colorectal cancer, followed by genetic testing of first-degree relatives if results from the index patient are positive. The editorialist discusses this and other modeling studies and examines what the present approach to genetic testing for the Lynch syndrome should be.

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