The full content of Annals is available to subscribers

Subscribe/Learn More  >
In the Clinic |


Jennifer F. Wilson
Ann Intern Med. 2010;152(3):ITC2-1. doi:10.7326/0003-4819-152-3-201002020-01002
Text Size: A A A

For several thousand years, gout has been recognized as a very painful form of acute and frequently recurrent arthritis. Gout is increasing in prevalence because of the higher prevalence of obesity, a high-caloric Western diet, diuretic use, and an aging population (1). Gout currently affects more than 5 million persons in the United States alone (2). It is the most common cause of inflammatory arthritis in men, with the highest incidence in men in their forties. Gout is caused by monosodium urate (MSU) crystals formed in joints and tissues when serum urate levels exceed 404.5 µmol/L (6.8 mg/dL), the approximate saturation point in human biological fluids. Gout causes acute mono- or polyarticular arthritis as well as chronic inflammation, which leads to joint destruction. Treatment is aimed at lowering serum urate levels and reducing the inflammatory response to the MSU crystals. After few advances in treatment for several decades, several new drugs for prevention of gout are now available.



First Page Preview

View Large
First page PDF preview





CME Activities are only available to ACP members and Individual Annals subscribers. If you are a member or a subscriber please sign in. Otherwise please become a member or subscribe to Annals.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Gout and African Americans: Reducing disparities. Cleve Clin J Med 2016;83(9):665-74.
[Olfaction in depressive disorders: Issues and perspectives]. Encephale Published online Sep 9, 2016;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.