Methods and Findings: A 51-year-old woman with a history of neck pain, hyperlipidemia, headaches, and fibromyalgia presented to a local emergency department with new occipital headache radiating to the face 1 week after a cervical epidural steroid injection on 31 August 2012 (Chen L, Lyons JL. Personal communication.). She had not received injections previously, had no history of immune compromise or trauma, and was not taking any long-term medications. Physical examination and unenhanced head computed tomography were normal, and she was discharged. No lumbar puncture was performed. She returned the next day with diplopia, vertigo, nausea, and ataxia and was hospitalized. Physical examination was notable only for hoarseness and decreased tendon reflexes; routine serum chemistry and blood counts were normal, and she had no fever. Magnetic resonance imaging (MRI) of the brain on hospital day 1 was normal. By day 3, she remained afebrile but developed slurred speech, right hemiparesis, left facial droop, and anisocoria, prompting repeated MRI. Results showed a punctate focus of diffusion restriction in the pons. Lumbar puncture had an opening pressure of 34 cm H2O, glucose level of 1.998 mmol/L (36 mg/dL) (serum glucose level of 5.828 mmol/L [105 mg/dL]), total protein level of 153 mg/dL, leukocyte count of 850 × 109 cells/L (84% neutrophils and 15% lymphocytes), and negative Gram stain and bacterial culture. Treatment with acyclovir, cefepime, vancomycin, doxycycline, and methylprednisolone was initiated; however, she continued to deteriorate and developed dysphagia, leading to endotracheal intubation and transfer to our tertiary care center on day 4 (Smith BR, Ostrow LW. Personal communication.). Magnetic resonance imaging on transfer showed multifocal areas of restricted diffusion in the pons, midbrain, and cerebellum and diffuse leptomeningeal enhancement (Figure, A and C). Repeat lumbar puncture on day 7 showed a glucose level of 2.719 mmol/L (49 mg/dL) (serum glucose level of 8.436 mmol/L [152 mg/dL]), protein level of 104 mg/dL, and leukocyte count of 72 × 109 cells/L (64% neutrophils, 4% lymphocytes, and 4% monocytes). Polymerase chain reaction testing of cerebrospinal fluid for herpes simplex virus, varicella zoster virus, Epstein–Barr virus, cytomegalovirus, and West Nile virus was negative, as were cryptococcal and histoplasma antigens and cerebrospinal fluid bacterial culture. Repeat MRI of the brain (Figure, B, D, and E) showed new restricted diffusion in the left anterior thalamus, progression of brainstem infarction and edema, and interval development of ventriculomegaly, prompting placement of an externalized ventricular drain that did not result in clinical improvement. Magnetic resonance imaging of the neck (Figure, F and G) showed inflammation and possible fluid collection in the soft tissues at the injection site, although follow-up ultrasonography did not corroborate fluid amenable to tap. On day 9, neurologic examination progressed to absent pupillary, corneal, and gag reflexes, and liposomal amphotericin B was added empirically. On day 10, all brainstem reflexes were lost, and death from neurologic criteria was pronounced. Exserohilum species was reported in the cerebrospinal fluid the same day. Autopsy revealed a grossly necrotic brainstem, and microscopic examination showed angioinvasive, septate fungal hyphae associated with diffuse vasculitis (Figure, H) and hemorrhagic infarction in the brain and spinal cord.