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Ann Intern Med. 1961;54(2):331-335. doi:10.7326/0003-4819-54-2-331
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Since 1888, when Osler recorded in detail the first full description of "hereditary angioneurotic edema," our knowledge of this baffling illness has advanced very little, if at all. The purpose of this paper is threefold: first, to add another family tree to the literature, which now embraces about 40 family histories; second, to familiarize the physician with unusual aspects of this form of urticaria, and to assess therapy now available; third, to show why this disease should be considered as nonallergic.

We feel that "angioneurotic" is a poor term, especially with regard to the familial variety of this disease, and




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