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Newer Advances in the Pathogenesis of Human Hypertension: The Adrenal Cortex and Renal Pressor Mechanism.

J. Genest, M.D., F.A.C.P.; P. Biron, M.D.; E. Koiw; W. Nowaczynski; R. Boucher; and M. Chrétien, M.D.
Ann Intern Med. 1961;54(5):1034. doi:10.7326/0003-4819-54-5-1034_1
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Recent studies from this laboratory have shown (1) an excessive fluctuation of daily urinary aldosterone in hypertensive patients, (2) a significant decrease (p < 0.001) in mean urinary pregnanetriol in groups of patients with essential, renal, and malignant hypertension, and (3) a urinary pregnanetriol/aldosterone ratio below the lower limits of normal range in 92% of hypertensive patients.

The possibility of a relationship between the renal pressor mechanism and the adrenal zona glomerulosa secreting aldosterone, as suggested by available experimental evidence, was explored. Forty experiments in normal volunteers and hypertensive patients were done with intravenous infusions (duration: 7 to 14 hours)


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