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Effects of Aminophylline on the Dynamics of Left Ventricular Failure.

S. M. Pariser, M.D., (Assoc.); S. M. Sancetta, M.D., F.A.C.P.; and H. Schwartz, M.D., F.A.C.P.
Ann Intern Med. 1961;54(5):1038. doi:10.7326/0003-4819-54-5-1038_2
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The favorable clinical effects of aminophylline in left ventricular failure are generally accepted. However, correlative physiologic data are scanty. Accordingly, the present study of the cardiopulmonary circulatory effects of intravenous aminophylline on the altered dynamics of left ventricular failure was undertaken. Particular emphasis was directed to the correlation of cardiac ouput and the left ventricular mean filling pressure. The pulmonary veno-capillary ("PC") pressure was used as the index of the left ventricular mean filling pressure.

Twelve patients with significant heart disease were studied. The etiologies included systemic hypertension, coronary heart disease, aortic and mitral valvular disease, and diffuse myocardial fibrosis.


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