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Prevention of Stokes-Adams Seizures by Reducing Plasma Potassium with Chlorothiazide.

L. Tobian, M.D., (Assoc.)
Ann Intern Med. 1961;54(5):1041. doi:10.7326/0003-4819-54-5-1041_1
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Seven patients with a long history of Stokes-Adams seizures were given chlorothiazide, enough to lower the plasma potassium at least 0.6 to 1.1 mEq./L. When this had been accomplished, the Stokes-Adams seizures were abolished. A good result was always obtained when the plasma potassium got as low as 3.8 mEq./L. The lessened incidence of seizures was not accompanied by any change in plasma pH even though the plasma bicarbonate rose slightly in some cases. Electrocardiographic tracings revealed several instances of decreasing heart block while on the treatment. The most striking improvement was a change from complete heart block to normal


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