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Axial Osteomalacia: An Unusual Bone Syndrome.

B. Frame, M.D., (Assoc.); R. S. Ormond, M.D.; H. M. Frost, M.D.; and R. B. Hunter, M.D.
Ann Intern Med. 1961;54(5):1043-1044. doi:10.7326/0003-4819-54-5-1043_3
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During the past year, four patients with unique coarsening and sponge-like appearance of the axial skeleton have been observed. Metabolic bone disease, as well as diffuse metastatic malignancy, was considered in the differential diagnosis. Studies of calcium and phosphorus metabolism revealed only minor and inconsistent abnormalities. Bone biopsies in three of the patients who were biopsied demonstrated wide osteoid seams and a marked increase in their number per unit volume, conditions compatible with osteomalacia.

The term axial osteomalacia has been chosen to indicate that the condition appears to be confined to the axial skeleton. It is postulated that the syndrome


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Axial osteomalacia: a new case report. Joint Bone Spine 2010;77(5):482-3.
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