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Abstracts |

Lupus Erythematosus and the Antigens of the Nucleus.

W. A. Atchley, M.D., (Assoc.)
Ann Intern Med. 1961;54(5):1051. doi:10.7326/0003-4819-54-5-1051_1
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The serum of patients with systemic lupus erythematosus (SLE) frequently contains antibodies which react with the isolated nucleus, fractions of the nucleus, and, less consistently, various components of the cytoplasm. This suggests but does not prove that SLE may be a disease of auto-immunity.

This laboratory has developed a new and fruitful method of studying the interaction between SLE serum and biochemical fractions of the cell, with particular emphasis on material derived from the nucleus. Leukocytes obtained from patients with leukemia are washed thoroughly and extracted in dilute glycine. The extract is extremely rich in deoxyribonucleic acid (DNA) and associated


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