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A Clinical and Serologic Study of the Latex Fixation Test in Leprosy.

E. S. Cathcart, M.D.; R. C. Williams Jr., M.D.; H. Ross, B.S.; and E. Calkins, M.D.
Ann Intern Med. 1961;54(5):1053-1054. doi:10.7326/0003-4819-54-5-1053_3
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While studying the latex fixation test in patients with nonrheumatic diseases, positive reactions were noted in a large proportion of leprosy sera. A study was therefore designed to determine the clinical and serologic significance of this observation. One hundred and one patients with leprosy, chosen at random, in the USPHS Hospital, Carville, were interviewed and examined personally by us. Data were obtained about each patient concerning his past and present medical history, physical examination, laboratory findings, joint x-rays, and special serologic tests.

Many of the patients were found to have chronic diseases other than leprosy, especially syphilis, diabetes, tuberculosis, and


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