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The Specific Serum Antimycobacterial Activity Test as a Guide to the Appropriate and Adequate Chemotherapy of Pulmonary Tuberculosis.

R. Gill, M.D.; I. Kass, M.D., F.A.C.P.; W. F. Russell Jr., M.D.; and W. E. Dye, Ph.D.
Ann Intern Med. 1961;54(5):1055. doi:10.7326/0003-4819-54-5-1055_1
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Serum microbiologic or chemical assay studies performed at National Jewish Hospital on antimicrobial agents such as streptomycin, isoniazid, cycloserine, pyrazinamide, and kanamycin, have clearly shown that patients achieve different serum concentrations of these antimicrobial agents even when dosages are adjusted according to body weight. Likewise, routine susceptibility studies have proved to be of value in determining the choice of the antituberculous drugs.

Although they are practical and satisfactory, serum microbiologic assays and in vitro drug susceptibility studies do require personnel and equipment which may not always be readily available. In an effort to determine whether appropriate and adequate antimicrobial therapy


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