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Abstracts |

The James D. Bruce Memorial Lecture on Preventive Medicine: Eradication of Poliomyelitis.

A. B. Sabin, M.D.
Ann Intern Med. 1961;54(5):1057. doi:10.7326/0003-4819-54-5-1057_2
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The extensive field trials of 1959 on millions of susceptible persons of various ages not only established the safety and effectiveness of the oral, live poliovirus vaccine that I developed, but also suggested the possibility that the disease as well as the causative paralytic viruses could, under certain conditions, be completely eliminated. This is theoretically possible with the oral live vaccine, which gives rise to varying degrees of resistance to reinfection of the intestinal tract, but not with the killed virus vaccine, which, while protecting the individual against paralysis, does not prevent him from becoming a carrier.

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