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The Labile Properties of the Pulmonary Vascular Bed in Patients with Pulmonary Emphysema.

R. H. Behnke, M.D., (Assoc.); J. F. Williams Jr., M.D.; and D. H. White, M.D.
Ann Intern Med. 1961;54(5):1059. doi:10.7326/0003-4819-54-5-1059_1
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The factors which produce pulmonary hypertension in patients with pulmonary emphysema are poorly understood. The present study was undertaken in such patients to determine whether this vascular bed functions as a fixed rigid system or is labile as shown by pharmacologic alteration of its tone.

Patients with pulmonary emphysema, established by clinical and laboratory tests, who were free of congestive heart failure, were studied at rest and with steady-state exercise prior to and during infusion of acetylcholine (2 to 8 mg./min.) and isoproterenol (.005 to .010 mg./min.) with determination of wedge, pulmonary, and systemic arterial pressures and cardiac output (CO).


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