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Physiology and Management of Pulmonary Insufficiency due to Kyphoscoliosis.

M. Stein, M.D.; and I. Bruderman, M.D.
Ann Intern Med. 1961;54(5):1060. doi:10.7326/0003-4819-54-5-1060_2
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Detailed studies of pulmonary function were carried out in seven patients with severe thoracic deformity (kyphoscoliosis). The ages ranged from 31 to 79 years and included both acquired and congenital deformities. Six patients complained of moderate or severe dyspnea on mild exertion and five had histories consistent with cor pulmonale. The pulmonary function studies revealed vital capacities to be smaller than predicted, normal distribution of inspired gas, normal tidal volumes, alveolar hypoventilation, carbon dioxide retention, and arterial blood oxygen saturation disproportionately low for the degree of hypoventilation. On breathing 99.6% oxygen, plasma oxygen concentration failed to rise to predicted normal


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