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Abstracts |

The Production of a Renal Lesion in Dogs by Injection of Plasma from Patients with Lupus Erythematosus.

G. O. Clifford, M.D.; and J. McClure, M.D.
Ann Intern Med. 1961;54(5):1062. doi:10.7326/0003-4819-54-5-1062_2
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It has been reported that infusion of plasma from patients with systemic lupus erythematosus produces L.E. cells in some dogs so treated. We have infused plasma (average 60 ml.) from patients with systemic lupus erythematosus at various stages of activity and treatment. L.E. preps were positive in about half the patients. The animals were infused once or twice on alternate days and sacrificed three to 10 days later. Control animals were infused with plasma from normal patients.

A renal lesion was seen in the majority of animals given plasma from patients with systemic lupus irrespective of the presence or absence

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