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T-Cell Intestinal Lymphoma Associated with Celiac Sprue

[+] Article, Author, and Disclosure Information

Grant support: by grant CH 254 from the American Cancer Society; and by grants CA 30924 and CA 18029 from the National Cancer Institute. Dr. Loughran is a Fellow of The Leukemia Society of America.

▸Requests for reprints should be addressed to Thomas P. Loughran, Jr., M.D.; Fred Hutchinson Cancer Research Center, 1124 Columbia Street; Seattle, WA 98104.

Seattle, Washington

© 1986 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1986;104(1):44-47. doi:10.7326/0003-4819-104-1-44
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A patient with a long history of celiac sprue developed a pleomorphic intestinal lymphoma. Cell suspensions of tumor cells and immunoperoxidase labeling of cell surface antigens in frozen tissue sections clearly showed the lymphoma to be of T-cell origin, despite the presence of other nontumor cells bearing enzyme markers of histiocytes. These findings may have important implications on the cellular origin of lymphomas developing in patients with celiac sprue.





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