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Pneumococcal Vaccine

[+] Article, Author, and Disclosure Information

Grant support: The development of this paper by the Clinical Efficacy Assessment Project was funded by the John A. Hartford Foundation.

▸Requests for reprints should be addressed to Linda Johnson White; Clinical Efficacy Assessment Project, Department of Health and Public Policy, American College of Physicians, 4200 Pine Street; Philadelphia, PA 19104.

© 1986 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1986;104(1):118-120. doi:10.7326/0003-4819-104-1-118
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This excerpt has been provided in the absence of an abstract.

A new vaccine for the prevention of bacteremic and nonbacteremic infection from Streptococcus pneumoniae has been licensed and is available. Like the previous pneumococcal vaccine, the new vaccine is composed of purified capsular pneumococcal antigens. The new vaccine is different from the previously available vaccine in two respects: it contains antigens to 23 serotypes of pneumococcus rather than the 14 serotypes in the previous formulation; and the dose of each antigen in the vaccine has been reduced from 50 µg to 25 µg. The 23 serotypes in the new vaccine account for approximately 85% of bacteremic pneumococcal disease in the


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