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Still Uncertain About Sodium–Glucose Cotransporter Inhibitors Despite 2 Centuries of Study

Steven A. Smith, MD
[+] Article, Author, and Disclosure Information

Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-0217.

Requests for Single Reprints: Steven A. Smith, MD, Mayo College of Medicine, 200 First Street SE, Rochester, MN 55905; e-mail, mailto:smith.steven@mayo.edu.

From Mayo College of Medicine, Rochester, MN 55905.

Ann Intern Med. 2012;156(6):466-467. doi:10.7326/0003-4819-156-6-201203200-00012
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Dapagliflozin offers a novel, insulin-independent mechanism of action for diabetes treatment. In this issue, Wilding and colleagues report on the effectiveness and safety of adding dapagliflozin to insulin therapy or insulin therapy with other oral hyperglycemic agents. The editorialist discusses the findings, as well as the U.S. Food and Drug Administration deliberation regarding approval of dapagliflozin.

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