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Cimetidine Impairs Elimination of Chlordiazepoxide (Librium) in Man

PAUL V. DESMOND, M.B., B.S.; RASHMI V. PATWARDHAN, M.D.; STEVEN SCHENKER, M.D.; and K. V. SPEEG Jr., M.D., Ph.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to K. V. Speeg, Jr., M.D.; Veterans Administration Medical Center, 1310 24th Avenue South; Nashville, TN 37203.


Nashville, Tennessee


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;93(2):266-268. doi:10.7326/0003-4819-93-2-266
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We have studied chlordiazepoxide (Librium) disposition and elimination in eight normal subjects before and after 1 week of Cimetidine therapy, 300 mg orally four times a day. Cimetidine strikingly impaired the clearance of chlordiazepoxide from plasma, and this was, at least in part, due to decreased demethylation of the drug to N-desmethylchlordiazepoxide. Since the volume of distribution of chlordiazepoxide was not altered by cimetidine, the elimination half-life of chlordiazepoxide was also significantly prolonged by cimetidine therapy.

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