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Effect of Calcitonin and Glucocorticoids in Combination on the Hypercalcemia of Malignancy

MARTIN L. BINSTOCK, M.D.; and GREGORY R. MUNDY, M.D.
[+] Article and Author Information

Grant support: in part by Grant CH-69B from the American Cancer Society, and Grant CA-25500 from the National Cancer Institute. Dr. Mundy is the recipient of Faculty Research Award FRA-148 from the American Cancer Society.

▸Requests for reprints should be addressed to Gregory R. Mundy, M.D.; Division of Endocrinology and Metabolism, Department of Medicine, University of Texas Health Sciences Center; San Antonio, TX 78284.


Farmington, Connecticut


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;93(2):269-272. doi:10.7326/0003-4819-93-2-269
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The effects of the combination of glucocorticoids and calcitonin on serum calcium levels were compared with the responses to calcitonin alone in 14 patients with malignant disease and hypercalcemia. The serum calcium concentrations of those patients treated with calcitonin alone returned to pretreatment concentrations within 48 hours, whereas those treated with the combination of calcitonin and glucocorticoids maintained the lower serum calcium concentrations for more than 4 days. These results suggest that the combination of calcitonin and glucocorticoids is a rapidly effective form of medical treatment for hypercalcemia and that glucocorticoids help to maintain the acute response to calcitonin in patients with hypercalcemia.

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