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Herpes Zoster in Patients with Small-Cell Carcinoma of the Lung Receiving Combined Modality Treatment

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The authors thank Ms. B. Ottema, R.N., and Mrs. L. Millband, R.N., for their assistance in data collection and Ms. S. Loft for her careful preparation of the manuscript.

Grant support: by the Ontario Cancer Treatment and Research Foundation project numbers 143 and 360 and a National Cancer Institute of Canada Clinical Trials Scholarship.

Princess Margaret and Toronto General Hospitals; Toronto, Ontario, Canada

Ann Intern Med. 1980;93(2):282-283. doi:10.7326/0003-4819-93-2-282
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This excerpt has been provided in the absence of an abstract.

Herpes zoster is seen in 4% to 25% of patients with Hodgkin's disease and is common in other hematologic malignancies (1-6). Patients with solid tumours are afflicted less often (0.5% to 1.8%) (1, 2, 5), and Wright and Winer (1) noted herpes zoster in only six of 738 (0.8%) patients with lung cancer.

Small-cell carcinoma accounts for about 20% of all cases of lung cancer but has received much attention recently because of encouraging preliminary results of treatment with combination chemotherapy and radiation (7, 8). We have observed an unexpectedly high frequency of herpes zoster in patients treated with combined


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