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Successful Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis With Eicosapentaenoic Acid

Junichi Hirahashi, MD, PhD; Airi Jo, MD; Kohei Ueda, MD; Akihiro Tojo, MD, PhD; and Toshiro Fujita, MD, PhD
[+] Article and Author Information

From Graduate School of Medicine, The University of Tokyo, 1138655 Tokyo, Japan.

Acknowledgment: The authors thank Makoto Arita and Keiichi Hishikawa for pharmacologic assistance; Masaomi Nangaku and George Seki for supervision and critical reading of the manuscript; and Ai Furuta for a vigorous clinical practice.

Grant Support: This work was supported in part by grants from the Ministry of Health, Labour and Welfare of Japan.

Potential Conflicts of Interest: The authors have applied for patents for the use of EPA to treat ANCA-associated vasculitis.


Ann Intern Med. 2012;156(10):755-756. doi:10.7326/0003-4819-156-10-201205150-00023
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Figure 1.

Renal biopsy specimen.

Glomerulus with a fibrocellular crescent (periodic acid–Schiff stain; original magnification, ×400).

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Figure 2.

Clinical course of renal function.

To convert serum creatinine levels to µmol/L, multiply by 88.4. ANCA = antineutrophil cytoplasmic antibody; anti-MPO = antimyeloperoxidase antibody; EPA = eicosapentaenoic acid; ND = not determined.

Grahic Jump Location

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