Four of the patients had liver injury that was due, at least in part, to the use of flavocoxid. All were women ranging in age from 57 to 68 years who were taking the supplement in doses of 250 to 500 mg twice daily for arthritis or musculoskeletal pain symptoms. Within 1 to 3 months after starting flavocoxid, the patients developed signs and symptoms of liver injury, including jaundice, abdominal pain, fever, itching and rash, and elevations in serum liver enzyme levels. Results of tests for other causes of liver injury were negative. The liver injury began to resolve within a few days after stopping flavocoxid, and serum enzyme levels decreased to normal within 1 to 3 months. There was no evidence of ongoing or chronic liver injury.