Insulin regulates the body's sugar, protein, and fat metabolism. In the insulin resistance syndrome, the body's tissues lose their sensitivity to insulin. To overcome this resistance, the body puts out more insulin, leading to high levels of insulin in the bloodstream. When the available insulin fails to overcome the tissue resistance, high blood sugars develop (diabetes), often accompanied by high blood pressure and high blood levels of triglycerides (a type of fat). The risk of developing this syndrome is greater in people who become overweight as adults. Recently, it has been suggested that being small at birth also increases the risk of developing the syndrome later in life. This increase in risk could be explained if the changes that occur in a developing baby's body in response to lack of nourishment during pregnancy become permanent. The insulin resistance syndrome has become more common in developing countries in recent years.