Advocates for fewer restrictions on firearms often invoke some version of the statement, “Guns don't kill people, people kill people.” Taken literally, this statement is true. However, without easy access to guns, people would be far less lethal. Also, many people who commit gun violence have mental health conditions. A 1990 survey found more than half of respondents reporting violent behavior during the prior year met Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III), criteria for at least 1 psychiatric disorder (6). Those reporting substance abuse disorders were more than twice as likely as those with schizophrenia to report violent behavior. A 2009 systematic review confirmed these associations (7). Because mental health is so often implicated in gun violence, it is logical that physicians and other health professionals engage in discussions to better identify individuals suffering from mental health conditions and make guns less easily and effective treatment more easily available to them. Requiring mental health screenings before gun purchases may seem overly invasive. Yet, our society is quite comfortable requiring a medical assessment before granting privileges for other activities, such as driving. It seems incongruous that we prohibit an individual with epilepsy from driving while allowing an individual with psychosis to purchase firearms and ammunition. Given the difficulty in identifying individuals at risk for violent behavior (8), defining policies that balance personal freedom and public safety will not be easy and must not be left to politicians alone. Regardless of whether our views about guns align with the National Rifle Association, Doctors for Responsible Gun Ownership, the National Physicians Alliance (http://npalliance.org), or somewhere between, we will have better policies if physicians who understand the interrelationship of mental health and violence actively engage in the policymaking that President Obama has promised in the aftermath of the Connecticut massacre.