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Diagnostic Accuracy of an “Amended” Insulin–Glucose Ratio for the Biochemical Diagnosis of Insulinomas

Michael A. Nauck, MD; and Jurus J. Meier, MD
[+] Article, Author, and Disclosure Information

From Diabeteszentrum Bad Lauterberg, Harz, and Ruhr-Universität Bochum, Bochum, Germany.

Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-0539.

Ann Intern Med. 2013;158(6):501-502. doi:10.7326/0003-4819-158-6-201303190-00021
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C-peptide and plasma glucose concentrations in study participants.

Top. Individual C-peptide concentrations and plasma glucose concentrations at the end of 48-hour prolonged fasts in control participants (black dots) in whom insulinoma was ruled out. Gray dots represent patients with insulinoma cured by pancreatic resection and studied after surgery. Bottom. C-peptide concentrations during hyperinsulinemic, stepped, hypoglycemic clamp experiments at plateaus of 4.3, 3.7, 3.0, and 2.3 mmol/L. Capillary plasma glucose concentrations in healthy participants (gray circles) were from a published study (3). Dotted lines connect values belonging to the same participant.

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March 19, 2013
Philip E. Cryer, MD; Lloyd Axelrod, MD; Ashley B. Grossman, MD; Simon R. Heller, MD; Elizabeth R. Seaquist, MD; F. John Service, MD, PhD;
AIM. 2013;158(6):500-501  doi:10.7326/0003-4819-158-6-201303190-00020

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