0
Summaries for Patients |

Discontinuation of Statins FREE

[+] Article and Author Information

The full report is titled “Discontinuation of Statins in Routine Care Settings. A Cohort Study.” It is in the 2 April 2013 issue of Annals of Internal Medicine (volume 158, pages 526-534). The authors are H. Zhang, J. Plutzky, S. Skentzos, F. Morrison, P. Mar, M. Shubina, and A. Turchin.


Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.

Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians.


Ann Intern Med. 2013;158(7):I-40. doi:10.7326/0003-4819-158-7-201304020-00001
Text Size: A A A

What is the problem and what is known about it so far?

Doctors frequently prescribe statins to lower blood cholesterol levels in people who have elevated cholesterol levels. In research studies, only a small proportion of people develop tiredness, muscle aches, or other symptoms that could be caused by statins, and even fewer stop taking their statins because of these symptoms. In practice, however, many more people stop taking statins because of symptoms that may be related to their statins and, thus, do not benefit from lower cholesterol levels.

Why did the researchers do this particular study?

The researchers created a software program that can read the unstructured text that clinicians enter in the electronic medical record to describe clinical visits. Then they showed that the software reliably identifies information about why people stop taking statins, in addition to the information that is available in the lists of diagnoses, allergies, and other structured parts of the electronic medical record.

Who was studied?

More than 100,000 adults who received a statin prescription during a 9-year period, beginning in 2000.

How was the study done?

Researchers used their software to find out who had statin-related events, whether people stopped taking their statins after these events, whether they later restarted a statin, and what happened if they did.

What did the researchers find?

Approximately one fifth of people had a symptom or other event that may have been related to the drug, and more than one half of these people stopped taking their statin, at least temporarily. More than one half of the people who stopped because of an event started taking a statin again (although not necessarily the same one), and more than 90% of them continued taking the statin after restarting.

What were the limitations of the study?

The study was done at 1 academic health system, which may limit the conclusions to similar settings. The software is not perfectly accurate.

What are the implications of the study?

Many statin-related events may be caused by something other than the statin, may be caused by the statin but are tolerable, or may be caused by 1 statin but not others.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)