Between August 2005 and November 2008, researchers enrolled patients from 16 Veterans Affairs medical
centers. There was a screening phase and a treatment phase. During the screening phase, patients received
standard medical care, including wound care, debridement, and pressure relief of the ulcer. Doctors could
also use extra treatments, such as ultraviolet light, laser therapy, hyperbaric oxygen, and electrical
stimulation. After 4 weeks, 108 patients with pressure ulcers that had not healed were randomly assigned to
receive 20 mg of oxandrolone daily and 104 were randomly assigned to receive placebo. Patients remained in
treatment until their ulcer had fully healed or for 24 weeks, whichever occurred first. The researchers also
followed patients whose ulcers healed to determine whether they stayed healed.