An ideal open-access framework that engages relevant stakeholders would provide a more balanced and reliable conclusion and interpretation of the data about a medical product compared with the existing paradigm of an individual stakeholder's analysis and interpretation. This open-access paradigm does require, however, a rigorous framework and feasible and effective process stages. First, there should be open access to all of the patient-level data from any given clinical data set of interest for all relevant stakeholders (10) under a usable data framework, such as the Integrating Data for Analysis, Anonymization, and Sharing model. After this data distribution, one would not be surprised to find either consistent or divergent conclusions and interpretations of the data based on the variable factors affecting the derivation of conclusions previously described. Second, there must be an agreed-on, convergent, or standardized set of data and analytic methods similar to the Clinical Data Interchange Standards Consortium or Health Level Seven standards to which stakeholders must comply so that their analyses may be shared. Third, there must be a public forum in which healthy discussion can occur, focused on adherence to analytic standards. Fourth, there must be a willingness and fervor to further iterate data analysis when the open discussion stage uncovers rational arguments that demand corrective actions. Adherence to this or a similar open framework with rigorous processes is critical to achieve the best possible convergence of the conclusions and interpretations (1).