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Severe Hypertension Related to Caffeinated Coffee and Tranylcypromine: A Case Report

Niels van der Hoeven, MD; Ieke Visser, MD; Aart Schene, MD, PhD; and Bert-Jan van den Born, MD, PhD
[+] Article, Author, and Disclosure Information

From Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands.

Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0038.

Ann Intern Med. 2014;160(9):657-658. doi:10.7326/L14-5009-8
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Grahic Jump Location

Ambulatory BP monitoring during consumption of caffeinated coffee combined with monoamine oxidase inhibitor therapy.

This patient's BP was elevated during the day followed by a steady decrease that started at 5:00 p.m. and continued during the night, producing a “morning dip.” On this day, the patient received 1 dose of tranylcypromine, which has a half-life of 2.5 h, at 1 h before monitoring and a second dose early in the afternoon. The 2 horizontal lines indicate normal average BP during the day (unshaded area) and at night (shaded area). His average daytime BP was 148/95 mm Hg (normal, <135/85 mm Hg), and his average nighttime BP was 107/71 mm Hg (normal, <120/70 mm Hg). Blood pressure between 1:30 p.m. and 3:30 p.m. could not be recorded (possibly as a result of extreme vasoconstriction or tachycardia), and the patient was fasting until the next morning when the monitoring device was removed. BP=blood pressure.

Grahic Jump Location




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